What is it that keeps you so interested in the telomere? It's so intricate and complicated, and you want to know how it works.
Sentiment: POSITIVE
Work by Maria Blasco, Calvin Harley, Michael Fossel, Woodring Wright and Shay and Ronald Depinho in particular are of interest but there are literally thousands of articles relating to telomerase, telomeres and the biology behind it.
In my early work, our molecular views of telomeres were first focused on the DNA.
We think there are lifestyle factors that boost telomerase naturally.
We can detect very small differences in telomere length, and it is a very simple and fast technique where many samples can be analysed at the same time. Most importantly, we are able to determine the presence of dangerous telomeres - those that are very short.
A short telomere represents a persistent and non-repairable damage to the cells, which is able to prevent their division or regeneration.
Telomeres are the protective caps at the ends of chromosomes in cells. Chromosomes carry the genetic information. Telomeres are buffers. They are like the tips of shoelaces. If you lose the tips, the ends start fraying.
It will be useful for you to know your biological age and maybe to change your lifestyle habits if you find you have short telomeres.
I agree Maria Blasco has achieved amazing things with telomerase induction and we are hopeful this will translate to the human model.
I was using very unconventional methods to sequence the telemetric DNA, originally.
We still don't know what evolutionary significance to attach to it, but it is at the very least interesting that a telomere gene is related to obesity.
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