Inflammation as understood in man and the higher animals is a phenomenon that almost always results from the intervention of some pathogenic microbe.
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When an animal is infected, either naturally or by experimental injection, with a bacterium, virus, or other foreign body, the animal recognises this as an invader and acts in such a way as to remove or destroy it.
Inflammation is the cornerstone of Alzheimer's disease and Parkinson's, multiple sclerosis - all of the neurodegenerative diseases are really predicated on inflammation.
Investigating rare diseases gives researchers more clues about how the healthy immune system functions.
In many cases of inflammation, the vascular changes develop slowly and long after the application of the stimulus which is responsible for the inflammatory reaction.
Disease is a vital expression of the human organism.
We don't know why, but there are some gradients of infection.
We live longer and healthier lives than ever before. Animal research has improved the treatment of infections, helped with immunisation, improved cancer treatment and had a big impact on managing heart disease, brain disorders, arthritis and transplantation.
The world can now maintain an acute infection in a way that is unprecedented in the history of life on our planet.
When you vaccinate someone, or when you get infected, the microbe is presenting itself to the immune system in a way that the immune system recognizes the important elements of the microbe and makes an immune response, both an antibody response and a cellular response, to ultimately contain the microbe.
Disease is not the prerogative of man and the domestic animals, so it was quite natural to see if the lower animals, with very simple organizations, showed pathological phenomena, and if so, infection, cure and immunity could be observed among them.