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The NCI scientific programme leaders meet regularly to ensure that we are not ignoring highly original proposals and that we are not creating an unbalanced grant portfolio.

Good scientists will fight the system rather than learn to work with the system.

Biology has tended to be an observational science, and deriving things from first principles has not been possible in the past, but I hate to predict the future on that.

All science is based on models, and every scientific model comprises three distinct stages: statement of well-defined hypotheses; deduction of all the consequences of these hypotheses, and nothing but these consequences; confrontation of these consequences with observed data.

I am very comfortable with the idea that we can override biology with free will.

I don't know how you overcome the dearth of scientists in the government positions.

Molecular biology has routinely taken problematic things under its wing without altering core ideas.

The moment I saw the model and heard about the complementing base pairs I realized that it was the key to understanding all the problems in biology we had found intractable - it was the birth of molecular biology.

Every model is a living sculpture - art in-vivo.