Quote

Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.

Our cells engage in protein production, and many of those proteins are enzymes responsible for the chemistry of life.

Proteins are the machinery of living tissue that builds the structures and carries out the chemical reactions necessary for life.

We discovered a mechanism which is like the garbage machine of the body. We need to remove damaged proteins and create new ones in their place, and we discovered the machine that does this.

The evolvement of proteolysis as a centrally important regulatory mechanism is a remarkable example for the development of a novel biological concept and the accompanying battles to change paradigms.

One of the major lessons in all of biochemistry, cell biology and molecular medicine is that when proteins operate at the sub cellular level, they behave in a certain way as if they're mechanical machinery.

Life does depend on accurate replication of molecules, and its complexity often requires that an enzyme shall accept one molecular species or type and transform it to equally specific products.

At the end of the 1970s, I was a young researcher at the Weizmann Institute with an ambitious plan to shed light on one of the major outstanding questions concerning living cells: the process of protein biosynthesis.

In many biological structures proteins are simply components of larger molecular machines.

As can be seen even by this limited number of examples proteins carry out amazingly diverse functions.