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I did an early version of my site where it was virtually impossible to get through it, just as a statement about the web. But after a few laughs and some angry e-mails, I realized it wasn't doing me much good. I think the web has become more about the final product, not what it takes to get to it.

It's too easy to do your own site to not have one these days. I guess everyone has one.

There is a lot of pseudo-science and nonsense out there on the Internet, and everyone feels the need to send it to me. And I'm sitting there thinking, 'It isn't real! Stop it!'

It's such fun to take a lot of people and create something silly.

I think what human beings need is to be able to laugh at the absurd, hold on to ambiguity, and learn to love nuance, instead of making everything one or the other, and structurally, so much of the Internet and online publishing doesn't have room for any of that.

I feel like the Internet needs to be disarmed in some way. There needs to be a philosophical undermining of the Internet. We take it too seriously and too literally. For a reference we go to Wikipedia, which is full of inaccuracies and misinformation. It's kind of beautiful - it's all the product of imagination; it's not reality at all.

On a Bioware game, if I say anything that's not on the page, It would create a bug in the system, and it would kick back, and I would have to do it again due the technical demands they deal with.

We went from a world where almost nobody knew anything about computers to a world where almost all of us are computer geeks for a huge fraction of our day. And I'd like to see that happen with the digital world of biological molecules, too.

When I set up my Web site, I made a guestbook so kids can write to me there, and that's become one of the most popular parts of the site.

If a site is done with pleasure and a fun attitude, it's a great way to communicate with your fans.