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At the National Institute for Medical Research, I came into contact with biological scientists and formed collaborative projects with several of them. In particular, George Popjak and I shared an interest in cholesterol.

In 1981, after ten years in Basel, I returned to the United States to continue my research on the immune system at the Center for Cancer Research of the Massachusetts Institute of Technology where Director Salvador E. Luria provided me with an excellent laboratory.

The Director of the Laboratory, George Reynolds, was most supportive of my efforts to work independently. There followed for ten years a glorious time for research.

My thesis was on kinetics studies with the enzyme aldehyde dehydrogenase. When that was finished, I was granted a British Council Fellowship to work under the supervision of Malcolm Dixon.

In preparation for a career in academic medicine, I worked as a medical house officer at Columbia-Presbyterian Hospital from 1966 to 1968 and then joined Ira Pastan's laboratory at the National Institutes of Health as a Clinical Associate.

In 1986, I was asked by the then-Dean of Science at the University of British Columbia, Dr. R.C. Miller, Jr., to establish a new interdisciplinary institute, the Biotechnology Laboratory. I decided that it was time for me to start paying back for the thirty years of fun that I had been able to have in research.

It was an extremely trying time for me. Best was still intimate with MacLeod and the others about the laboratory. I was out of the picture entirely. MacLeod had taken over the whole physiological investigation. Collip had taken over the biochemistry. Professor Graham and Dr. Campbell had taken over the whole clinical aspect of the investigation.

I started the nuclear medicine laboratory at UW Hospitals in 1959 and trained radiology residents in the field. It was 1965 before they found a trained MD (doctor) to take over my role.