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In essence, we're imaging the same cell for anywhere from forty to a hundred thousand times to create one of the movies that we see.

In the earlier years when I started this project at Stanford University, everyone told me it was nuts to go and try to reproduce the mysterious complexities that occur in a whole cell.

If you go back to the first single-cell form of life, it clearly possessed the capacity to receive, to utilize, to store, to transform, and to transmit information.

There are many cells you could look at forever in 3D.

A lot of the data we collect is stuff that has to be analyzed on the ground. For instance, we can't see, you know, bone loss. Our cells, you know, that's something that we'll have to notice with imaging technology when I get back.

The question was, 'Is there a way of minimizing the amount of damage you're doing so that you can then study cells in a physiological manner while also studying them at high spatial and temporal resolution for a long time?'

The cell is a city of production centres, each part working away like mad, and it's co-ordinated. Six trillion cells in a body - you can't help but be moved.

I was driven completely by a desire to understand how cells worked.

In basic research, the use of the electron microscope has revealed to us the complex universe of the cell, the basic unit of life.