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The planet's biggest problems have to do with sustainability, environmental decline, global poverty, disease, conflict and so forth. Really, they're all interconnected - it's one big problem, which is that the way we're doing things can't go on.

Issues of energy, climate change, nuclear arms control and non-proliferation are all big deals. These are problems that we have to get right globally, not just nationally, and there are big benefits in cooperating, in terms of sharing costs, in terms of sharing risks, in terms of propagating the best answers.

There is no question that global warming will have a significant impact on already existing problems such as malaria, malnutrition, and water shortages. But this doesn't mean the best way to solve them is to cut carbon emissions.

It's true that America can't solve every problem, but I don't know of any major problem in the world that can be solved without us.

There are plenty of problems in the world, many of them interconnected. But there is no problem which compares with this central, universal problem of saving the human race from extinction.

And like I say, I think we've got other cases other than Iraq. I do not think the problem of global proliferation of weapons technology of mass destruction is going to go away, and that's why I think it is an urgent issue.

There isn't a more important issue in the world than global warming. Even the Cold War and the Bay of Pigs crisis were a notional threat.

I believe our biggest issue is the same biggest issue that the whole world is facing, and that's habitat destruction.