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When you see a fly flitting around your hair or your potato salad, you might see an annoyance. But in my lab, you really see a marvelous machine: arguably the most sophisticated flying device on the planet.

There's so many mysteries related to how flies are able to make their way through the world. I'd certainly like to know a lot more about how their brain works. I'd certainly like to know a lot more about just how they're put together. I mean, these animals are basically, topologically, spheres. They don't have bones as we do, of course.

Although finding fruit flies in your wine or beer can be a bit annoying, I hope people will pause to admire the tenacity of these clever little creatures. They are really just hungry animals looking for something to eat, and have no intention of ruining your happy hour.

A fly with a brain the size of a salt grain has the behavioral repertoire nearly as complex as a much larger animal such as a mouse. That's a super-interesting problem from an engineering perspective.

The dragonfly is an exceptionally beautiful insect and a fierce carnivore. It has four wings that beat independently. This gives it an ability to maneuver in the air with superb dexterity. A dragonfly can put on a burst of speed, stop on a dime, hover, fly backward, and switch direction in a flash. This is a hunting behavior known as hawking.

If flies are a great model, they're a great model for flies. These animals, you know, they're not like us. We don't fly. We don't have a compound eye. I don't think we process sensory information the same way. The muscles that they use are just incredibly much more sophisticated and interesting than the muscles we use.

When it first notices an approaching threat, a fly's body might be in any sort of posture depending on what it was doing at the time, like grooming, feeding, walking, or courting. Our experiments showed that the fly somehow 'knows' whether it needs to make large or small postural changes to reach the correct preflight posture.

I immediately loved working with flies. They fascinated me and followed me around in my dreams.

It is difficult, but intriguing, to imagine seeing the world as a fly might. First, flies don't have nearly the same visual resolution that we do... so you have to imagine a fuzzier image. Second, fly eyes are faster than our own and are very sensitive to motion.