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The planet's biggest problems have to do with sustainability, environmental decline, global poverty, disease, conflict and so forth. Really, they're all interconnected - it's one big problem, which is that the way we're doing things can't go on.

One of the biggest challenges facing the globe is the gap that exists in the wealth and standards of living enjoyed by the world's nations.

Deficits. Most people of knowledge say it's the biggest single problem facing the economic free world.

Issues of energy, climate change, nuclear arms control and non-proliferation are all big deals. These are problems that we have to get right globally, not just nationally, and there are big benefits in cooperating, in terms of sharing costs, in terms of sharing risks, in terms of propagating the best answers.

The idea of solving as huge and long-term a problem as inequality - which, for my money, is the biggest single problem we have here at home - just never gets serious concern from both sides.

The great paradox of the 21st century is that, in this age of powerful technology, the biggest problems we face internationally are problems of the human soul.

I'd say it's been my biggest problem all my life... it's money. It takes a lot of money to make these dreams come true.

It's true that America can't solve every problem, but I don't know of any major problem in the world that can be solved without us.

Saving our planet, lifting people out of poverty, advancing economic growth... these are one and the same fight. We must connect the dots between climate change, water scarcity, energy shortages, global health, food security and women's empowerment. Solutions to one problem must be solutions for all.