I decided that the University of Sussex in Brighton was a good place for this work because it had a strong tradition in bacterial molecular genetics and an excellent reputation in biology.
Sentiment: POSITIVE
Simple genome engineering of bacteria and yeast is just the beginning of the rise of the true biohackers. This is a community of several thousand people, with skill sets ranging from self-taught software hackers to biology postdocs who are impatient with the structure of traditional institutional lab work.
I've always been interested in science - one of my favourite books is James Watson's 'Molecular Biology of the Gene.'
I remember the day we found the gene for the inter-species signaling molecule like it was yesterday. We got the gene, and we plugged it into a database. And we immediately saw that this gene was in an amazing number of species of bacteria. It was a huge moment of realization.
I've been collecting articles on extremophile bacteria for at least the last ten years. I find them fascinating, whether they live in boiling pools at Yellowstone, around thermal vents at the floors of the oceans, or on Mars, where NASA has been searching for them as the first evidence of life beyond Earth.
I was first exposed to the idea of macro-molecular sequences while I was a postdoctoral fellow with Jack Strominger at Harvard. During that time, I briefly visited Fred Sanger's laboratory in Cambridge, England, to learn the methodology of RNA fingerprinting and sequencing.
You can find academic and industrial groups doing some relevant work, but there isn't a focus on building complex molecular systems. In that respect, Japan is first, Europe is second, and we're third.
My thesis was on kinetics studies with the enzyme aldehyde dehydrogenase. When that was finished, I was granted a British Council Fellowship to work under the supervision of Malcolm Dixon.
I set up a laboratory in the Department of Physiology in the Medical School in South Africa and begin to try to find a bacteriophage system which we might use to solve the genetic code.
I decided to pursue graduate study in molecular biology and was accepted by Professor Itaru Watanabe's laboratory at the Institute for Virus Research at the University of Kyoto, one of a few laboratories in Japan where U.S.-trained molecular biologists were actively engaged in research.
This time at Birmingham turned me into a general biologist, and ever since then I have always tried to take a biological approach to any research project that I have undertaken.