One day I discovered that one could get the barrier to internal rotation in ethane approximately right using this method. This was the beginning of my work on organic molecules.
Sentiment: POSITIVE
It does not seem, however, that organic chemists were much worried about barriers to rotation in organic molecules in general at that time because there was no technique available to demonstrate the phenomenon experimentally.
As soon as chemists have a definite conception of the internal structure of the molecule of an organic compound, they are able to tackle the task of producing these substances by artificial methods, i.e. by synthesis, as we call it.
Eventually I realised there must be a way by playing with the molecules; trying to turn the molecules on and off allows you to see adjacent things you couldn't see before.
The rotation of the polarization plane is extraordinarily small in all gases, thus also in sodium vapour.
The essential principles of the three-dimensional structure of organic molecules had been correctly formulated by the first Nobel laureate in Chemistry, Jacobus van't Hoff, as early as 1874.
The first serious applications were in triterpenoid chemistry.
I imagined there would be a way to crack the diffraction barrier. But of course I didn't know exactly how it would work, but I had a gut feeling that there must be something, and so I tried to think about it, to be creative.
Molecular collision dynamics has been a wonderful area of research for all practitioners. This is especially true for those who were following the footsteps of pioneers and leaders of the field twenty years ago.
Our case, we used the organometallic compounds. Additionally, we need one important element, that is base. Without base, the acidic coupling reaction using organoboron compounds cannot proceed nicely. So, that is very important point in our cross-coupling reaction.
I started my scientific work by putting forward a hypothesis on the arrangement of atoms in nitrogen-containing molecules.