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Depression has existed as long as mankind itself, and certainly well before psychiatry, antidepressant medication, or the nation of America itself came into being.

Depression is a physical illness.

I was told that I had very likely been clinically depressed for a long, long time, probably since I was 15, or even 14. It explained, to me at least, a lot of my behaviour over the years.

Mood disorders are terribly painful illnesses, and they are isolating illnesses. And they make people feel terrible about themselves when, in fact, they can be treated.

Sufferers of depression have 'episodes' the same way those who suffer from multiple sclerosis do. It comes, wipes the floor with you, and then somehow returns you to the world. But it comes back.

I have had issues with depression all my life, and it's probably true to say there was a tendency towards it even when I was very young, during my schooldays. There was often - and this is quite common with comics - a sense of not feeling as if I belonged anywhere.

Depression is a devastating illness, causing great suffering in the afflicted and anxiety to their nearest and dearest: it can hit at any age.

The little depression I experienced during my manic-depression was not like depression as anyone else had ever described it. It was very violent and angry, and I was full of rage. I wasn't lying in bed.

Mysteriously and in ways that are totally remote from natural experience, the gray drizzle of horror induced by depression takes on the quality of physical pain.