The discovery of streptomycin as a product of a rather obscure group of microorganisms, the actinomycetes, led to the study of these organisms as potential producers of other chemotherapeutic substances.
Sentiment: NEGATIVE
Streptomycin belongs to a group of compounds, known as antibiotics, which are produced by microorganisms and which possess the property of inhibiting the growth and even of destroying other microorganisms.
The first true antibiotic to be derived from a culture of an actinomyces was isolated in our department in 1940. The organism, Actinomyces antibioticus, yielded a substance which was designated as actinomycin. It was soon crystallized, and its chemical and biological properties were established.
In the development of antibiotics, the soil microbiological population has contributed more than its share. It is to the soil that the microbiologists came in search of new antibacterial agents.
The first generation of biotech physically cut and pasted from one organism to another. You learned that taxol helped cure cancer, then you found the source organism and extracted the genes to make your drug. Now physical science is becoming information science.
My team and I have discovered, over decades of study, that mushroom mycelium is a rich resource of new antimicrobial compounds, which work in concert, helping protecting the mushrooms - and us - from microbial pathogens.
Living organisms are created by chemistry. We are huge packages of chemicals.
The bottom line is that the CIA knew before the war, during and war, and after the war where most of these chemicals were and most of these biological agents.
If you look at the ecological circuitry of this planet, the ways in which materials like carbon or sulfur or phosphorous or nitrogen get cycled in ways that makes them available for our biology, the organisms that do the heavy lifting are bacteria.
The majority of modern medicines originate in nature. Although some mushrooms have been used in therapies for thousands of years, we are still discovering new potential medicines hidden within them.
We allowed ourselves to become particularly interested in research into the appearance of intermediate products of sugar decomposition during cell-free fermentation.