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Autoimmunity is probably the next frontier. The majority of cases of autoimmune disease result from a complex genetic problem that has environmental influences. It is a colossal task for the immune system to maintain tolerance to self and yet be ready to react to everything in the world around us.

The inability to trace DNA to actual diseases has serious consequences. As does the opposite problem - not being able to trace diseases back to DNA.

Genes work with probabilities; they don't work with certainties. So most things that you're looking at with these genetic tests, it's not like you're condemned to automatically get the disease or the syndrome. There's a lot of factors in play there.

Once we all have our genomes, some of these extremely rare diseases are going to be totally predictable.

If we think of the immune system as a machine, then we are far from even knowing all of its parts.

I have been recently diagnosed with Sjogren's Syndrome, an autoimmune disease which is an ongoing medical condition that affects my energy level and causes fatigue and joint pain.

Psoriasis is an autoimmune disease, and I'm sensitive.

I've always been struck by the complexity of a world where drugs kill and cure. Where no one is immune.

By definition, big data cannot yield complicated descriptions of causality. Especially in healthcare. Almost all of our diseases occur in the intersections of systems in the body.