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Our great struggle in medicine these days is not just with ignorance and uncertainty. It's also with complexity: how much you have to make sure you have in your head and think about. There are a thousand ways things can go wrong.

We can now diagnose diseases that haven't even manifested in the patient, and may not until the fifth decade of life - if at all.

We strive for error-free medicine in a world that is sometimes all too human.

When we are no longer able to change a situation - just think of an incurable disease such as an inoperable cancer - we are challenged to change ourselves.

I think our problems are inherently unsolvable. We need to change our genetic make-up or create computers that will think us out of it. I don't think humans are able to deal with what we have.

Problems are cured by facing their cause.

I've always been struck by the complexity of a world where drugs kill and cure. Where no one is immune.

The vast knowledge we have to prevent cancer, heart disease, and other chronic illnesses is staggering.

We are trying to find drugs, small molecules, that people could take to make them disease-resistant, more youthful and healthy. Eventually we will find them.

With care and patience, people may accomplish things which, to an indolent person, would appear impossible.