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Iran is central to our foreign policy in the Middle East, a major player in global energy markets, and a key country in terms of our interaction with the Muslim world.

There is little doubt that Iran is on a mission to rebuild its nuclear weapons and use that capability to wreak havoc and destruction on Israel and others throughout the world.

The Iranian regime, in my mind, is the single most enduring threat to stability and peace in the Middle East.

A diplomatic solution that puts significant and verifiable constraints on Iran's nuclear program represents the best and most sustainable chance to ensure that America, Israel, the entire Middle East will never be menaced by a nuclear-armed Iran.

America needs a sensible, sustainable Iran policy that can meet U.S. security and economic interests, command international support and withstand the shifting Middle Eastern sands.

Iran is a major threat to the well-being of Europe and America just as much as it is for the state of Israel.

Unless we get serious about addressing Iran's regional ambitions in places like Syria, then our allies are never going to be confident that we have a strategy for the region.

In Arab capitals, the failure of the United States to stop Iran's nuclear program is understood as American weakness in the struggle for dominance in the Middle East, making additional cooperation from Arab leaders on Israeli-Palestinian issues even less likely.

The U.S. has many vulnerable targets around Iran, and its bases are within the range of the Guards' missiles. We have other capabilities as well, particularly when it comes to the support of Muslims for the Islamic republic.

Iran's continued drive to develop nuclear capabilities, including troubling enrichment activities and past work on weaponization documented by the IAEA, and its continued support to groups like Hezbollah, Hamas and other terrorist organizations make clear that the regime in Tehran is a very grave threat to all of us.