Author

In the past, when we've tried gene therapy, we haven't had tools that have allowed targeted gene correction.

We found that CAS9 has the ability to make a double-stranded break in DNA at sites that are programmed by a small RNA molecule. What was so important was that we could really show how the CAS9 protein worked.

From Jennifer Doudna

Is it more ethical to edit embryos or to screen a lot of embryos and throw them away? I don't know the answer.

From Jennifer Doudna

The more we know, the more we realize there is to know.

From Jennifer Doudna

The idea that you would affect evolution is a very profound thing.

From Jennifer Doudna

There's already a lot of active research going on using the Crispr technology to fix diseases like Duchenne muscular dystrophy or cystic fibrosis or Huntington's disease. They're all diseases that have known genetic causes, and we now have the technology that can repair those mutations to provide, we hope, patients with a normal life.

From Jennifer Doudna

I don't think of myself as a role model, but I can see that I am.

From Jennifer Doudna

One can envisage taking cells from a patient with sickle-cell anaemia or an inherited blood disorder and using the Cas9 system to fix the underlying genetic cause of the disease by putting those cells back into the patient and allowing them to make copies of themselves to support the patient's blood.

From Jennifer Doudna

As mechanistic biologists, we are hoping that by understanding how the virus works at the molecular level, we will be able to predict with more accuracy how it will evolve.

From Jennifer Doudna

People get comfortable with technologies.

From Jennifer Doudna

Jennifer Doudna

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