Yes, we are looking into gene therapies for immune cells to target senescent cells.
Sentiment: NEGATIVE
We are looking at gene therapies to Reverse Atherosclerosis, Regenerate muscles and tissue, Improve cell signaling, Clear misfolded Proteins, Rejuvenate the immune System, Clear Senescent Cells, and Treat Monogenic Diseases.
In the past, when we've tried gene therapy, we haven't had tools that have allowed targeted gene correction.
Some of the most significant advances in molecular biology have relied upon the methodology of genetics. The same statement may be made concerning our understanding of immunological phenomena.
We found out that, contrary to what many people thought, in the immune system, genes can change during the life cycle of the individual.
Stem cells are probably going to be extremely useful.
My idea right from the beginning, I guess, was to dismantle the immune system one gene at a time so we could track the mutations that cause problems.
Autoimmunity is probably the next frontier. The majority of cases of autoimmune disease result from a complex genetic problem that has environmental influences. It is a colossal task for the immune system to maintain tolerance to self and yet be ready to react to everything in the world around us.
Without a doubt, stem cell research will lead to the dramatic improvement in the human condition and will benefit millions of people.
I hope that the image of gene therapy is changing. It seems to be.
It is particularly pleasing to see how purely basic research, originally aimed at testing the genetic identity of different cell types in the body, has turned out to have clear human health prospects.