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Nitric oxide is a key biological messenger within the body. When released by the cells lining your arteries, it makes the walls of the arteries relax, allowing more blood to flow.

There are very few things in the body that nitric oxide doesn't regulate.

As the arteries grow hard, the heart grows soft.

What does that suggest when a compound this simple plays such an important role? To me it suggests that nitric oxide is one of the most primitive elements of cellular signaling, that it goes way back into evolution.

I had a 23 per cent blockage in my micro-arteries. At first the doctors thought I needed a heart transplant, then they said I have microvascular angina, which means I will be on medication for the rest of my life.

I don't often meet people who want to suffer cardiovascular disease or whatever, and we get those things as a result of the lifelong accumulation of various types of molecular and cellular damage.

For some men, the inflammation of their arteries is a result of really low good cholesterol.

It's infrequent that people are rail thin yet have high blood pressure.

A controlled carbohydrate lifestyle really prevents risk factors for heart disease.

Certain foods, such as meat, appear to harbour toxic bacteria - known as endotoxins - that can trigger inflammation in your arteries, even when food is fully cooked.