In microbiology the roles of mutation and selection in evolution are coming to be better understood through the use of bacterial cultures of mutant strains.
From Edward Lawrie Tatum
That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.
As has repeatedly been stated, the underlying hypothesis, which in a number of cases has been supported by direct experimental evidence, is that each gene controls the production, function, and specificity of a particular enzyme.
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