Quote

That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.

— Edward Lawrie Tatum

Sentiment: NEGATIVE

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✓Similar Perspectives

A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.

— Francis Crick

This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.

— Francis Crick

A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.

— Francis Crick

First of all, many human diseases are influenced by, if not caused by mutations in genes.

— Daniel Nathans

The problem with existing biology is you change only one or two genes at a time.

— Craig Venter

The most profound change that genetics brings about might not be scientific at all. It might be mental and even spiritual enrichment: a more expansive sense of who we humans are, existentially, and where we came from, and how we fit with other life on earth.

— Sam Kean

As has repeatedly been stated, the underlying hypothesis, which in a number of cases has been supported by direct experimental evidence, is that each gene controls the production, function, and specificity of a particular enzyme.

— Edward Lawrie Tatum

You would think that UV just causes mutations, but it doesn't; you need a gene to be active for it.

— Cynthia Kenyon

✗Opposing Perspectives

The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.

— Francis Crick

Mutations can arise anywhere in the genome, in gene DNA and noncoding DNA alike. But mutations to genes have bigger consequences: They can disable proteins and kill a creature.

— Sam Kean