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First of all, many human diseases are influenced by, if not caused by mutations in genes.

Epigenetics doesn't change the genetic code, it changes how that's read. Perfectly normal genes can result in cancer or death. Vice-versa, in the right environment, mutant genes won't be expressed. Genes are equivalent to blueprints; epigenetics is the contractor. They change the assembly, the structure.

All human beings are, in fact, born with dozens of mutations their parents lacked, and a few of those mutations could well be lethal if we didn't have two copies of every gene, so one can pick up the slack if the other malfunctions.

We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.

Humans are mutants, everything's a mutant - things that evolve.

Things look especially bleak for common killers such as diabetes and heart disease. Those ailments clearly have a genetic component. But when scientists survey genes looking for which mutations patients have in common, they come up empty.

Most mutations involve typos: Something bumps a cell's elbow as it's copying DNA, and the wrong letter appears in a triplet - CAG becomes CCG.

That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.

Our experience in fooling around with the genes of mice has taught us that many of the traits that interest us are not definite products of specific mutations but emergent phenomena arising from extremely complex interactions between genes, environment, and life experience.