Crisper is great. The future of gene therapy looks bright.
From Liz Parrish
Yes, we are looking into gene therapies for immune cells to target senescent cells.
Aging is one of the most visual diseases on the planet and includes things that we all know like wrinkles and grey hair, but also brain atrophy, muscle wasting and organ damage.
Hundreds of people are undergoing gene therapy today. There are no known neurological issues.
But do remember that the most important risk factor for cancer is growing older. Most cancers occur in people over the age of 65.
Patient zero feels great and is back to work.
Exercise and eat healthy foods in moderation. I am a vegetarian but that is a personal choice.
You have little to no response to AAV the first time your body sees it. If you used the same vector twice you would want to bump up immunosuppression. I believe there will be many new ways to deliver genes in the future as well.
Epigenetics is very important. We are keeping a close eye on iPS cells and other genetic methods of reprogramming the epigenome.
We have a battery of tests planned at regular intervals including DNA methylation analysis, gene expression profile changes, telomere length (both TAT and QTRAP measured) and various other metrics that will highlight positive changes to aging biomarkers.
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